eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis

To better understand a role of eIF4E S209 in oncogenic translation, we generated EIF4E(S209A/+) heterozygous knockin (4EKI) HCT 116 human colorectal cancer (CRC) cells. 4EKI had little impact on total eIF4E levels, cap binding or global translation, but markedly reduced HCT 116 cell growth in sphero...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ruan, Hang, Li, Xiangyun, Xu, Xiang, Leibowitz, Brian J, Tong, Jingshan, Chen, Lujia, Ao, Luoquan, Xing, Wei, Luo, Jianhua, Yu, Yanping, Schoen, Robert E, Sonenberg, Nahum, Lu, Xinghua, Zhang, Lin, Yu, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7665890/
https://ncbi.nlm.nih.gov/pubmed/33135632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60151
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