Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells

The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of blood glucose homeostasis. Ligand-specific differences in membrane trafficking of the GLP-1R influence its signalling properties and therapeutic potential in type 2 diabetes. Here, we have evaluated how different factors comb...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Fang, Zijian, Chen, Shiqian, Manchanda, Yusman, Bitsi, Stavroula, Pickford, Philip, David, Alessia, Shchepinova, Maria M., Corrêa Jr, Ivan R., Hodson, David J., Broichhagen, Johannes, Tate, Edward W., Reimann, Frank, Salem, Victoria, Rutter, Guy A., Tan, Tricia, Bloom, Stephen R., Tomas, Alejandra, Jones, Ben
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7664906/
https://ncbi.nlm.nih.gov/pubmed/33182425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21218404
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