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Enhanced Dopamine Transmission and Hyperactivity in the Dopamine Transporter Heterozygous Mice Lacking the D3 Dopamine Receptor

Dopamine transporter knockout (DATk) mice are known to demonstrate profound hyperactivity concurrent with elevated (5-fold) extracellular dopamine in the basal ganglia. At the same time, heterozygous DAT mice (DATh) demonstrate a 2-fold increase in dopamine levels yet only a marginal elevation in lo...

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Foilsithe in:Int J Mol Sci
Main Authors: Sotnikova, Tatyana D., Efimova, Evgeniya V., Gainetdinov, Raul R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7662256/
https://ncbi.nlm.nih.gov/pubmed/33153031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21218216
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