Enhanced Dopamine Transmission and Hyperactivity in the Dopamine Transporter Heterozygous Mice Lacking the D3 Dopamine Receptor

Dopamine transporter knockout (DATk) mice are known to demonstrate profound hyperactivity concurrent with elevated (5-fold) extracellular dopamine in the basal ganglia. At the same time, heterozygous DAT mice (DATh) demonstrate a 2-fold increase in dopamine levels yet only a marginal elevation in lo...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Sotnikova, Tatyana D., Efimova, Evgeniya V., Gainetdinov, Raul R.
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7662256/
https://ncbi.nlm.nih.gov/pubmed/33153031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21218216
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