Design of Fluorescent Coumarin-Hydroxamic Acid Derivatives as Inhibitors of HDACs: Synthesis, Anti-Proliferative Evaluation and Docking Studies

Coumarin-hydroxamic acid derivatives 7a–k were herein designed with a dual purpose: as antiproliferative agents and fluorescent probes. The compounds were synthesized in moderate yields (30–87%) through a simple methodology, biological evaluation was carried out on prostate (PC3) and breast cancer (...

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Vydáno v:Molecules
Hlavní autoři: García, Santiago, Mercado-Sánchez, Itzel, Bahena, Luis, Alcaraz, Yolanda, García-Revilla, Marco A., Robles, Juvencio, Santos-Martínez, Nancy, Ordaz-Rosado, David, García-Becerra, Rocío, Vazquez, Miguel A.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7662212/
https://ncbi.nlm.nih.gov/pubmed/33158250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25215134
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