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Comparison of size distribution and (Pro249-Ser258) epitope exposure in in vitro and in vivo derived Tau fibrils

BACKGROUND: Although several studies demonstrate prion-like properties of Tau fibrils, the effect of size in the seeding capacity of these aggregates is not fully understood. The aim of this study is to characterize Tau seeds by their size and seeding capacity. METHODS: Tau aggregates were isolated...

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Detalhes bibliográficos
Publicado no:BMC Mol Cell Biol
Main Authors: Marreiro, André, Van Kolen, Kristof, Sousa, Cristiano, Temmerman, Liesbet, Vasconcelos, Bruno, Crespo-Rodriguez, Rosa, van Weering, Jan R. T., Van Dam, Debby, De Deyn, Peter P., Apetri, Adrian, Schoofs, Liliane, Mercken, Marc H.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7661158/
https://ncbi.nlm.nih.gov/pubmed/33183222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-020-00320-y
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