Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser(422) containing epitope on pathological tau

Aggregation of tau protein and spreading of tau aggregates are pivotal pathological processes in a range of neurological disorders. Accumulating evidence suggests that immunotherapy targeting tau may be a viable therapeutic strategy. We have previously described the isolation of antibody CBTAU-22.1...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: van Ameijde, Jeroen, Crespo, Rosa, Janson, Roosmarijn, Juraszek, Jarek, Siregar, Berdien, Verveen, Hanneke, Sprengers, Imke, Nahar, Tariq, Hoozemans, Jeroen J., Steinbacher, Stefan, Willems, Roland, Delbroek, Lore, Borgers, Marianne, Dockx, Koen, Van Kolen, Kristof, Mercken, Marc, Pascual, Gabriel, Koudstaal, Wouter, Apetri, Adrian
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6042391/
https://ncbi.nlm.nih.gov/pubmed/30001207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0562-9
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