Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser(422) containing epitope on pathological tau

Aggregation of tau protein and spreading of tau aggregates are pivotal pathological processes in a range of neurological disorders. Accumulating evidence suggests that immunotherapy targeting tau may be a viable therapeutic strategy. We have previously described the isolation of antibody CBTAU-22.1...

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Bibliografski detalji
Izdano u:Acta Neuropathol Commun
Glavni autori: van Ameijde, Jeroen, Crespo, Rosa, Janson, Roosmarijn, Juraszek, Jarek, Siregar, Berdien, Verveen, Hanneke, Sprengers, Imke, Nahar, Tariq, Hoozemans, Jeroen J., Steinbacher, Stefan, Willems, Roland, Delbroek, Lore, Borgers, Marianne, Dockx, Koen, Van Kolen, Kristof, Mercken, Marc, Pascual, Gabriel, Koudstaal, Wouter, Apetri, Adrian
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6042391/
https://ncbi.nlm.nih.gov/pubmed/30001207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0562-9
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