Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

Enteroviruses are suspected to contribute to insulin-producing β cell loss and hyperglycemia-induced diabetes. However, mechanisms are not fully defined. Here, we show that coxsackievirus B type 4 (CVB4) infection in human islet-engrafted mice and in rat insulinoma cells displays loss of unconventio...

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Pubblicato in:Cell Rep Med
Autori principali: Bernard, Hugo, Teijeiro, Ana, Chaves-Pérez, Almudena, Perna, Cristian, Satish, Basanthi, Novials, Anna, Wang, Jennifer P., Djouder, Nabil
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7659558/
https://ncbi.nlm.nih.gov/pubmed/33205075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100125
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