Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

Enteroviruses are suspected to contribute to insulin-producing β cell loss and hyperglycemia-induced diabetes. However, mechanisms are not fully defined. Here, we show that coxsackievirus B type 4 (CVB4) infection in human islet-engrafted mice and in rat insulinoma cells displays loss of unconventio...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Rep Med
Main Authors: Bernard, Hugo, Teijeiro, Ana, Chaves-Pérez, Almudena, Perna, Cristian, Satish, Basanthi, Novials, Anna, Wang, Jennifer P., Djouder, Nabil
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7659558/
https://ncbi.nlm.nih.gov/pubmed/33205075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100125
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados