Stroma secreted IL6 selects for “stem-like” population and alters pancreatic tumor microenvironment by reprogramming metabolic pathways

Pancreatic adenocarcinoma is a devastating disease with an abysmal survival rate of 9%. A robust fibro-inflammatory and desmoplastic stroma, characteristic of pancreatic cancer, contribute to the challenges in developing viable therapeutic strategies in this disease. Apart from constricting blood ve...

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Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Kesh, Kousik, Garrido, Vanessa T., Dosch, Austin, Durden, Brittany, Gupta, Vineet K., Sharma, Nikita S., Lyle, Michael, Nagathihalli, Nagaraj, Merchant, Nipun, Saluja, Ashok, Banerjee, Sulagna
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7658205/
https://ncbi.nlm.nih.gov/pubmed/33177492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03168-4
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