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Distinct cation gradients power cholesterol transport at different key points in the Hedgehog signaling pathway
Cholesterol plays two critical roles in Hedgehog signaling, a fundamental pathway in animal development and cancer: it covalently modifies the Sonic hedgehog (SHH) ligand, restricting its release from producing cells, and directly activates Smoothened in responding cells. In both contexts, a membran...
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| Publicado no: | Dev Cell |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7658045/ https://ncbi.nlm.nih.gov/pubmed/32860743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.08.002 |
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