Laddar...
Cellular cholesterol directly activates Smoothened in Hedgehog signaling
In vertebrates, sterols are necessary for Hedgehog signaling, a pathway critical in embryogenesis and cancer. Sterols activate the membrane protein Smoothened by binding its extracellular, cysteine-rich domain (CRD). Major unanswered questions concern the nature of the endogenous, activating sterol...
Sparad:
| I publikationen: | Cell |
|---|---|
| Huvudupphovsmän: | , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2016
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5035717/ https://ncbi.nlm.nih.gov/pubmed/27545348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.08.003 |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|