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Cellular cholesterol directly activates Smoothened in Hedgehog signaling

In vertebrates, sterols are necessary for Hedgehog signaling, a pathway critical in embryogenesis and cancer. Sterols activate the membrane protein Smoothened by binding its extracellular, cysteine-rich domain (CRD). Major unanswered questions concern the nature of the endogenous, activating sterol...

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Bibliografiska uppgifter
I publikationen:Cell
Huvudupphovsmän: Huang, Pengxiang, Nedelcu, Daniel, Watanabe, Miyako, Jao, Cindy, Kim, Youngchang, Liu, Jing, Salic, Adrian
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035717/
https://ncbi.nlm.nih.gov/pubmed/27545348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.08.003
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