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Cellular cholesterol directly activates Smoothened in Hedgehog signaling
In vertebrates, sterols are necessary for Hedgehog signaling, a pathway critical in embryogenesis and cancer. Sterols activate the membrane protein Smoothened by binding its extracellular, cysteine-rich domain (CRD). Major unanswered questions concern the nature of the endogenous, activating sterol...
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| Veröffentlicht in: | Cell |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5035717/ https://ncbi.nlm.nih.gov/pubmed/27545348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.08.003 |
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