The structural basis of Smoothened activation in Hedgehog signaling

The seven transmembrane-spanning protein Smoothened is the central transducer in Hedgehog signaling, a pathway fundamental in development and cancer. Smoothened is activated by cholesterol binding to its extracellular cysteine-rich domain (CRD). How this interaction leads to changes in the transmemb...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cell
Asıl Yazarlar: Huang, Pengxiang, Zheng, Sanduo, Wierbowski, Bradley M., Kim, Youngchang, Nedelcu, Daniel, Aravena, Laura, Liu, Jing, Kruse, Andrew C., Salic, Adrian
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046275/
https://ncbi.nlm.nih.gov/pubmed/29804838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.04.029
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