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Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders

Substantial genetic liability is shared across psychiatric disorders but less is known about risk variants that are specific to a given disorder. We used multi-trait conditional and joint analysis (mtCOJO) to adjust GWAS summary statistics of one disorder for the effects of genetically correlated tr...

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הוצא לאור ב:	Mol Psychiatry
Main Authors:	Byrne, Enda M, Zhu, Zhihong, Qi, Ting, Skene, Nathan G, Bryois, Julien, Pardinas, Antonio F, Stahl, Eli, Smoller, Jordan W, Rietschel, Marcella, Owen, Michael J, Walters, James T.R., O’Donovan, Michael C, McGrath, John G, Hjerling-Leffler, Jens, Sullivan, Patrick F, Goddard, Michael E, Visscher, Peter M, Yang, Jian, Wray, Naomi R
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2020
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7657979/ https://ncbi.nlm.nih.gov/pubmed/32398722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-020-0705-9
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Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders

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