Inhibition of transforming growth factor-β signaling in myeloid cells ameliorates aortic aneurysmal formation in Marfan syndrome

Increased transforming growth factor-β (TGF-β) signaling contributes to the pathophysiology of aortic aneurysm in Marfan syndrome (MFS). Recent reports indicate that a small but significant number of inflammatory cells are infiltrated into the aortic media and adventitia in MFS. However, little is k...

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Bibliographic Details
Published in:PLoS One
Main Authors: Hara, Hironori, Maemura, Sonoko, Fujiwara, Takayuki, Takeda, Norifumi, Ishii, Satoshi, Yagi, Hiroki, Suzuki, Takaaki, Harada, Mutsuo, Toko, Haruhiro, Kanaya, Tsubasa, Ijichi, Hideaki, Moses, Harold L., Takimoto, Eiki, Morita, Hiroyuki, Akazawa, Hiroshi, Komuro, Issei
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657512/
https://ncbi.nlm.nih.gov/pubmed/33175881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239908
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