Detection of epidermal growth factor receptor T790M mutation in plasma DNA from patients refractory to epidermal growth factor receptor tyrosine kinase inhibitor

A secondary epidermal growth factor receptor (EGFR) mutation, the substitution of threonine 790 with methionine (T790M), leads to acquired resistance to reversible EGFR‐tyrosine kinase inhibitors (EGFR‐TKIs). A non‐invasive method for detecting T790M mutation would be desirable to direct patient tre...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Sakai, Kazuko, Horiike, Atsushi, Irwin, Darryl L., Kudo, Keita, Fujita, Yoshihiko, Tanimoto, Azusa, Sakatani, Toshio, Saito, Ryota, Kaburaki, Kyohei, Yanagitani, Noriko, Ohyanagi, Fumiyoshi, Nishio, Makoto, Nishio, Kazuto
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7656545/
https://ncbi.nlm.nih.gov/pubmed/23721103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12211
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