TMEM59 Haploinsufficiency Ameliorates the Pathology and Cognitive Impairment in the 5xFAD Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disease associated with cognitive deficits and synaptic impairments. Amyloid-β (Aβ) plaque deposition, dystrophic neurite accumulation and neurofibrillary tangles are pathological hallmarks of AD. TMEM59 has been implicated to play a role i...

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Bibliographische Detailangaben
Veröffentlicht in:Front Cell Dev Biol
Hauptverfasser: Meng, Jian, Han, Linkun, Zheng, Naizhen, Xu, Hui, Liu, Zhaoji, Zhang, Xian, Luo, Hong, Can, Dan, Sun, Hao, Xu, Huaxi, Zhang, Yun-wu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Cell and Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655972/
https://ncbi.nlm.nih.gov/pubmed/33195275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.596030
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