Heterogeneity of TP53 Mutations and P53 Protein Residual Function in Cancer: Does It Matter?

The human TP53 locus, located on the short arm of chromosome 17, encodes a tumour suppressor protein which functions as a tetrameric transcription factor capable of regulating the expression of a plethora of target genes involved in cell cycle arrest, apoptosis, DNA repair, autophagy, and metabolism...

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Detaylı Bibliyografya
Yayımlandı:Front Oncol
Asıl Yazarlar: Monti, Paola, Menichini, Paola, Speciale, Andrea, Cutrona, Giovanna, Fais, Franco, Taiana, Elisa, Neri, Antonino, Bomben, Riccardo, Gentile, Massimo, Gattei, Valter, Ferrarini, Manlio, Morabito, Fortunato, Fronza, Gilberto
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2020
Konular:
Oncology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655923/
https://ncbi.nlm.nih.gov/pubmed/33194757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.593383
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