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Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure

Neural tube closure defects are a major cause of infant mortality, with exencephaly accounting for nearly one-third of cases. However, the mechanisms of cranial neural tube closure are not well understood. Here, we show that this process involves a tissue-wide pattern of apical constriction controll...

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Veröffentlicht in:eLife
Hauptverfasser: Brooks, Eric R, Islam, Mohammed Tarek, Anderson, Kathryn V, Zallen, Jennifer A
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655103/
https://ncbi.nlm.nih.gov/pubmed/33103996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60234
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