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Establishing and Interpreting Graded Sonic Hedgehog Signaling during Vertebrate Neural Tube Patterning: The Role of Negative Feedback
The secreted protein Sonic Hedgehog (SHH) acts in graded fashion to pattern the dorsal–ventral axis of the vertebrate neural tube. This is a dynamic process in which increasing concentrations and durations of exposure to SHH generate neurons with successively more ventral identities. Interactions be...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2742090/ https://ncbi.nlm.nih.gov/pubmed/20066087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a002014 |
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