Whole-genome sequencing reveals new Alzheimer’s disease-associated rare variants in loci related to synaptic function and neuronal development

INTRODUCTION: Genome-wide association studies have led to numerous genetic loci associated with Alzheimer’s disease (AD). Whole-genome sequencing (WGS) now permit genome-wide analyses to identify rare variants contributing to AD risk. METHODS: We performed single-variant and spatial clustering-based...

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Udgivet i:medRxiv
Main Authors: Prokopenko, Dmitry, Morgan, Sarah L., Mullin, Kristina, Hofmann, Oliver, Chapman, Brad, Kirchner, Rory, Amberkar, Sandeep, Wohlers, Inken, Lange, Christoph, Hide, Winston, Bertram, Lars, Tanzi, Rudolph E.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654884/
https://ncbi.nlm.nih.gov/pubmed/33173892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.11.03.20225540
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