Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets

Containment of the COVID-19 pandemic requires reducing viral transmission. SARS-CoV-2 infection is initiated by membrane fusion between the viral and host cell membranes, mediated by the viral spike protein. We have designed a dimeric lipopeptide fusion inhibitor that blocks this critical first step...

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Publié dans:bioRxiv
Auteurs principaux: de Vries, Rory D., Schmitz, Katharina S., Bovier, Francesca T., Noack, Danny, Haagmans, Bart L., Biswas, Sudipta, Rockx, Barry, Gellman, Samuel H., Alabi, Christopher A., de Swart, Rik L., Moscona, Anne, Porotto, Matteo
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654853/
https://ncbi.nlm.nih.gov/pubmed/33173865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.11.04.361154
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