Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets

Containment of the COVID-19 pandemic requires reducing viral transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by membrane fusion between the viral and host cell membranes, which is mediated by the viral spike protein. We have designed lipopeptide fusi...

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Veröffentlicht in:Science
Hauptverfasser: de Vries, Rory D., Schmitz, Katharina S., Bovier, Francesca T., Predella, Camilla, Khao, Jonathan, Noack, Danny, Haagmans, Bart L., Herfst, Sander, Stearns, Kyle N., Drew-Bear, Jennifer, Biswas, Sudipta, Rockx, Barry, McGill, Gal, Dorrello, N. Valerio, Gellman, Samuel H., Alabi, Christopher A., de Swart, Rik L., Moscona, Anne, Porotto, Matteo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011693/
https://ncbi.nlm.nih.gov/pubmed/33597220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abf4896
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