Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets

Containment of the COVID-19 pandemic requires reducing viral transmission. SARS-CoV-2 infection is initiated by membrane fusion between the viral and host cell membranes, mediated by the viral spike protein. We have designed a dimeric lipopeptide fusion inhibitor that blocks this critical first step...

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Gepubliceerd in:bioRxiv
Hoofdauteurs: de Vries, Rory D., Schmitz, Katharina S., Bovier, Francesca T., Noack, Danny, Haagmans, Bart L., Biswas, Sudipta, Rockx, Barry, Gellman, Samuel H., Alabi, Christopher A., de Swart, Rik L., Moscona, Anne, Porotto, Matteo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654853/
https://ncbi.nlm.nih.gov/pubmed/33173865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.11.04.361154
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