SARS-CoV-2 RBD219-N1C1: A Yeast-Expressed SARS-CoV-2 Recombinant Receptor-Binding Domain Candidate Vaccine Stimulates Virus Neutralizing Antibodies and T-cell Immunity in Mice

There is an urgent need for an accessible and low-cost COVID-19 vaccine suitable for low- and middle-income countries. Here we report on the development of a SARS-CoV-2 receptor-binding domain (RBD) protein, expressed at high levels in yeast ( Pichia pastoris ), as a suitable vaccine candidate again...

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Publicado no:bioRxiv
Main Authors: Pollet, Jeroen, Chen, Wen-Hsiang, Versteeg, Leroy, Keegan, Brian, Zhan, Bin, Wei, Junfei, Liu, Zhuyun, Lee, Jungsoon, Kundu, Rahki, Adhikari, Rakesh, Poveda, Cristina, Villar, Maria Jose, de Araujo Leao, Ana Carolina, Rivera, Joanne Altieri, Momin, Zoha, Gillespie, Portia M., Kimata, Jason T., Strych, Ulrich, Hotez, Peter J., Bottazzi, Maria Elena
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654852/
https://ncbi.nlm.nih.gov/pubmed/33173864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.11.04.367359
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