Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Aluminum Hydroxide Induces Protective Immunity and Reduces Immune Enhancement

We developed a severe acute respiratory syndrome (SARS) subunit recombinant protein vaccine candidate based on a high-yielding, yeast- engineered, receptor-binding domain (RBD219-N1) of the SARS beta-coronavirus (SARS-CoV) spike (S) protein. When formulated with Alhydrogel®, RBD219-N1 induced high-l...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Chen, Wen-Hsiang, Tao, Xinrong, Agrawal, Anurodh, Algaissi, Abdullah, Peng, Bi-Hung, Pollet, Jeroen, Strych, Ulrich, Bottazzi, Maria Elena, Hotez, Peter J., Lustigman, Sara, Du, Lanying, Jiang, Shibo, Tseng, Chien-Te K.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263514/
https://ncbi.nlm.nih.gov/pubmed/32511385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.05.15.098079
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