Endothelial deficiency of insulin-like growth factor-1 receptor reduces endothelial barrier function and promotes atherosclerosis in Apoe-deficient mice

Insulin-like growth factor-1 (IGF-1) decreases atherosclerosis in apolipoprotein E (Apoe)-deficient mice when administered systemically. However, mechanisms for its atheroprotective effect are not fully understood. We generated endothelium-specific IGF-1 receptor (IGF1R)-deficient mice on an Apoe-de...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Higashi, Yusuke, Sukhanov, Sergiy, Shai, Shaw-Yung, Danchuk, Svitlana, Snarski, Patricia, Li, Zhaohui, Hou, Xuwei, Hamblin, Milton H., Woods, T. Cooper, Wang, Meifang, Wang, Derek, Yu, Hong, Korthuis, Ronald J., Yoshida, Tadashi, Delafontaine, Patrice
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654661/
https://ncbi.nlm.nih.gov/pubmed/32795184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00064.2020
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