Identification of small molecule inhibitors of p27(Kip1) ubiquitination by high‐throughput screening

Dysregulation of p27(Kip1) due to proteolysis that involves the ubiquitin ligase (SCF) complex with S‐phase kinase‐associated protein 2 (Skp2) as the substrate‐recognition component (SCF (Skp2)) frequently results in tumorigenesis. In this report, we developed a high‐throughput screening system to i...

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Dettagli Bibliografici
Pubblicato in:Cancer Sci
Autori principali: Ooi, Li‐Ching, Watanabe, Nobumoto, Futamura, Yushi, Sulaiman, Shaida Fariza, Darah, Ibrahim, Osada, Hiroyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2013
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654252/
https://ncbi.nlm.nih.gov/pubmed/23910095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12246
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