Small compound bigelovin exerts inhibitory effects and triggers proteolysis of E2F1 in multiple myeloma cells

Multiple myeloma (MM) is a currently incurable blood cancer. Here we tested the effects of a small compound bigelovin on MM cells, and reported that it caused cell cycle arrest and subsequently induced apoptosis. Bigelovin triggered proteolysis of E2F1, which could be inhibited by caspase inhibitor....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Sci
Egile Nagusiak: Liu, Jing‐Lei, Zeng, Guang‐Zhi, Liu, Xiao‐Li, Liu, Yong‐Qiang, Hu, Zhong‐Guo, Liu, Ying, Tan, Ning‐Hua, Zhou, Guang‐Biao
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2013
Gaiak:
Original Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654247/
https://ncbi.nlm.nih.gov/pubmed/24118350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12295
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