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Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic model

BACKGROUND: A defining pathological hallmark of the progressive neurodegenerative disorder Alzheimer’s disease (AD) is the accumulation of misfolded tau with abnormal post-translational modifications (PTMs). These include phosphorylation at Threonine 231 (T231) and acetylation at Lysine 274 (K274) a...

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Bibliografiske detaljer
Udgivet i:Mol Neurodegener
Main Authors: Guha, Sanjib, Fischer, Sarah, Johnson, Gail V. W., Nehrke, Keith
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654055/
https://ncbi.nlm.nih.gov/pubmed/33168053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00410-7
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