UGT1A1*6,1A7*3, and 1A9*22 genotypes predict severe neutropenia in FOLFIRI‐treated metastatic colorectal cancer in two prospective studies in Japan

Retrospective studies have suggested that UDP‐glucuronosyltransferase (UGT)1A1,UGT1A7, and UGT1A9 predict severe toxicity and efficacy of irinotecan‐containing regimens. We prospectively evaluated the impact of UGT1A genotypes and haplotypes on severe toxicity and efficacy in patients treated with f...

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Dettagli Bibliografici
Pubblicato in:Cancer Sci
Autori principali: Hazama, Shoichi, Mishima, Hideyuki, Tsunedomi, Ryouichi, Okuyama, Yusuke, Kato, Takeshi, Takahashi, Ken‐ichi, Nozawa, Hiroshi, Ando, Hideaki, Kobayashi, Michiya, Takemoto, Hiroyoshi, Nagata, Naoki, Kanekiyo, Shinsuke, Inoue, Yuka, Hamamoto, Yoshihiko, Fujita, Yusuke, Hinoda, Yuji, Okayama, Naoko, Oba, Koji, Sakamoto, Jun‐ichi, Oka, Masaaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2013
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7653527/
https://ncbi.nlm.nih.gov/pubmed/24033692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12283
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