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Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology
To establish whether 4-nitroquinoline N-oxide-induced carcinogenesis mirrors the heterogeneity of human oral squamous cell carcinoma (OSCC), we have performed genomic analysis of mouse tongue lesions. The mutational signatures of human and mouse OSCC overlap extensively. Mutational burden is higher...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7652942/ https://ncbi.nlm.nih.gov/pubmed/33168804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19401-9 |
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