Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology

To establish whether 4-nitroquinoline N-oxide-induced carcinogenesis mirrors the heterogeneity of human oral squamous cell carcinoma (OSCC), we have performed genomic analysis of mouse tongue lesions. The mutational signatures of human and mouse OSCC overlap extensively. Mutational burden is higher...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Sequeira, Inês, Rashid, Mamunur, Tomás, Inês M., Williams, Marc J., Graham, Trevor A., Adams, David J., Vigilante, Alessandra, Watt, Fiona M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7652942/
https://ncbi.nlm.nih.gov/pubmed/33168804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19401-9
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