Sites of vulnerability on ricin B chain revealed through epitope mapping of toxin-neutralizing monoclonal antibodies

Ricin toxin’s B subunit (RTB) is a multifunctional galactose (Gal)-/N-acetylgalactosamine (GalNac)-specific lectin that promotes uptake and intracellular trafficking of ricin’s ribosome-inactivating subunit (RTA) into mammalian cells. Structurally, RTB consists of two globular domains (RTB-D1, RTB-D...

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Bibliographic Details
Published in:PLoS One
Main Authors: Vance, David J., Poon, Amanda Y., Mantis, Nicholas J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7652295/
https://ncbi.nlm.nih.gov/pubmed/33166282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0236538
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