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Intracellular Neutralization of Ricin Toxin by Single Domain Antibodies Targeting the Active Site
The extreme potency of the plant toxin, ricin, is due to its enzymatic subunit, RTA, which inactivates mammalian ribosomes with near perfect efficiency. Here we characterized, at the functional and structural levels, seven alpaca single-domain antibodies (V(H)Hs) previously reported to recognize epi...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7066583/ https://ncbi.nlm.nih.gov/pubmed/31931008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.01.006 |
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