EXTH-38. ORTHOGONAL IN VIVO MODELS WERE THE SOLE PRECLINICAL PREDICTOR OF CLINICAL EFFICACY IN PHASE 1 TRIALS OF TARGETED THERAPIES FOR GLIOBLASTOMA: RESULTS OF A SYSTEMATIC REVIEW

INTRODUCTION: No drug has improved survival in recurrent glioblastoma despite encouraging activity preclinically. We undertook a systematic review of matched preclinical and Phase 1 trials (P1Ts) of targeted agents to investigate potential preclinical predictors of clinical efficacy. METHODS: We ide...

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Bibliografische gegevens
Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Gunjur, Ashray, Balasubramanian, Adithya, Hafeez, Umbreen, Menon, Siddharth, Cher, Lawrence, Parakh, Sagun, Gan, Hui
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2020
Onderwerpen:
Preclinical Experimental Therapeutics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651640/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.392
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