Inefficiencies in phase II to phase III transition impeding successful drug development in glioblastoma

BACKGROUND: Improving outcomes of patients with glioblastoma (GBM) represents a significant challenge in neuro-oncology. We undertook a systematic review of key parameters of phase II and III trials in GBM to identify and quantify the impact of trial design on this phenomenon. METHODS: Studies betwe...

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Publicat a:Neurooncol Adv
Autors principals: Balasubramanian, Adithya, Gunjur, Ashray, Hafeez, Umbreen, Menon, Siddharth, Cher, Lawrence M, Parakh, Sagun, Gan, Hui Kong
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Reviews
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7850118/
https://ncbi.nlm.nih.gov/pubmed/33543145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa171
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