TMOD-18. TARGETING THE PI3K/AKT PATHWAY IN MYCN AMPLIFIED HIGH GRADE GLIOMAS

Pediatric glioblastoma (pGBM) are incurable brain tumors with overall poor prognosis and response to treatments due to molecular and epigenetic heterogeneity. In particular, the MYCN subtype of pGBM are a highly aggressive form of GBM with a dismal median survival of only 14 months. Furthermore, thi...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Halligan, Katharine, Stanton, Ann-Catherine, Halbert, Matthew, Golbourn, Brian, Mack, Stephen, Pollack, Ian, Agnihotri, Sameer
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Tumor Models
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651550/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.969
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