DDRE-13. DECONVOLUTING MECHANISMS OF RESISTANCE TO BRAF INHIBITORS IN BRAF V600E HUMAN GLIOMA

BACKGROUND: While BRAF-targeted therapy can be effective in a subset of patients with glioma, resistance to treatment can emerge over time. The description and validation of mechanisms of resistance in BRAF-mutant glioma are not previously described. METHODS: Pre- and post- BRAF inhibitor (BRAFi) or...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Schreck, Karisa, Morin, Andrew, Zhao, Guisheng, Sanford, Bridget, Green, Adam, Jones, Kenneth, Banerjee, Anurhada, Nazemi, Kellie, Samuel, David, Kilburn, Lindsay, Solomon, David, Pratilas, Christine, Nicolaides, Theodore, Levy, Jean Mulcahy
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Drug Discovery, Drug Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651491/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.258
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