EXTH-34. PHASE I TRIAL OF CONVECTION-ENHANCED DELIVERY OF IL13RA2 AND EPHA2 RECEPTOR TARGETED CYTOTOXINS IN DOGS WITH SPONTANEOUS INTRACRANIAL GLIOMAS

The interleukin 13 receptor alpha 2 (IL13RA2) and ephrin type-A receptor 2 (EPHA2) receptors are attractive therapeutic targets, being expressed in ~90% of canine and human gliomas, and absent in normal brain. Clinical trials using an earlier generation IL-13 based cytotoxin showed encouraging clini...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Rossmeisl, John, Herpai, Denise, D’Agostino, Ralph, Tatter, Stephen, Dickinson, Peter, Debinski, Waldemar
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Preclinical Experimental Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651380/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.388
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