TAMI-08. A TALE OF TWO TELOMERE MAINTENANCE MECHANISMS: TERT EXPRESSION AND THE ALT PATHWAY INDUCE UNIQUE MRS-DETECTABLE METABOLIC REPROGRAMMING IN LOW-GRADE GLIOMAS

Telomeres are nucleoprotein structures at chromosomal ends that shorten with cell division and constitute a natural barrier to proliferation. In order to proliferate indefinitely, all tumors require a telomere maintenance mechanism (TMM). Telomerase reverse transcriptase (TERT) expression is the TMM...

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Publicat a:Neuro Oncol
Autors principals: Viswanath, Pavithra, Batsios, Georgios, Gillespie, Anne Marie, Luchman, Hema Artee, Costello, Joseph, Pieper, Russell, Ronen, Sabrina
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Tumor Microenvironment/Angiogenesis/Metabolism/Invasion
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651189/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.897
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