EXTH-61. COMBINATION OF DISULFIRAM AND COPPER INDUCES NPL4 AGGREGATION, TARGETS CD133-NESTIN CELLS AND EXTENDS SURVIVAL IN MEDULLOBLASTOMA GROUP 3 MODELS

BACKGROUND: Medulloblastoma (MB), the most common brain malignancy among children, is classified into four molecular subtypes, WNT-driven, Shh-driven, Group 3 and 4. The aim of this study was to assess the effects of the combination of Disulfiram, an inhibitor of Aldehyde Dehydrogenase, and Copper i...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Serra, Riccardo, Zhao, Tianna, Huq, Sakibul, Gorelick, Noah, Casaos, Joshua, Cecia, Arba, Mangraviti, Antonella, Olivi, Alessandro, Brem, Henry, Jackson, Eric M, Tyler, Betty
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Preclinical Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651060/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.415
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