EPCO-09. STEREOTACTIC IMAGE-GUIDED EPIGENOME PROFILING REVEALS DIVERSE EVOLUTIONARY GROWTH ROUTES IN DIFFUSE GLIOMAS

Intratumoral heterogeneity is a hallmark of diffuse gliomas and inhibits effective prediction of clinical outcome. To devise a three-dimensional reconstruction of tumor lineage, we used neuronavigation to acquire eight to twelve image-guided and spatially separated stereotactic biopsy samples from 1...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Barthel, Floris, Verburg, Niels, Anderson, Kevin, Koopman, Thomas, Johnson, Kevin, Wesseling, Pieter, de Witt Hamer, Philip, Verhaak, Roel
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
(Epi)Genetics and Computational Omics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651024/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.288
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