IMMU-24. TEMOZOLOMIDE INDUCED IMMUNE DYSFUNCTION REQUIRES THE PRESENCE OF INTRACRANIAL TUMORS

Temozolomide was recently shown to cause peripheral and intra-tumoral T cell dysfunction in a dosing schedule dependent fashion. Standard dose (SD) temozolomide (TMZ) resulted in T cell dysfunction precluding response to immune checkpoint inhibition that was avoided with a metronomic dosing (MD) sch...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Karachi, Aida, Dastmalchi, Farhad, O’Malley, Ashley, Yang, Changlin, Mitchell, Duane, Rahman, Maryam
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650937/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.454
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