CSIG-19. THE DEUBIQUITINASE BRCC3 LINKS ALT TELOMERES TO SUPPRESSION OF INNATE IMMUNITY IN IDH1-MUTANT GLIOMA

Approximately 10% of tumors including all IDH1-mutant lower-grade glioma resolve telomeric shortening using Alternative Lengthening of Telomere (ALT) mechanism. Although the ALT process lengthens telomeres, it also generates small bits of extrachromosomal, telomere-containing DNA (ECTRs). These ECTR...

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Publicat a:Neuro Oncol
Autors principals: Mukherjee, Joydeep, Tang, Yongjian, Johanessen, Tor-Christian, Pandita, Ajay, Ohba, Shigeo, Cahill, Daniel, Pieper, Russell
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Cell Signaling and Signaling Pathways
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650433/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.131
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