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Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance
Isocitrate dehydrogenase 1 (IDH1) mutations occur in most lower-grade glioma, and not only drive gliomagenesis but are associated with longer patient survival and improved response to temozolomide (TMZ). To investigate the possible causative relationship between these events, we introduced wild-type...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4154998/ https://ncbi.nlm.nih.gov/pubmed/25035396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0924 |
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