CSIG-07. c-Src PHOSPHORYLATES AND INACTIVATES THE CIC TUMOR SUPPRESSOR PROTEIN IN GLIOBLASTOMA

Capicua (CIC) is a transcriptional repressor that counteracts activation of genes in response to receptor tyrosine kinase (RTK)/Ras/MEK/ERK signaling. Following activation of RTK, ERK enters the nucleus and serine-phosphorylates CIC, releasing it from its targets to permit gene expression. We recent...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Bunda, Severa, Heir, Pardeep, Li, Annie, Yasin, Mamatjan, Zadeh, Gelareh, Aldape, Kenneth
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Cell Signaling and Signaling Pathways
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650335/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.119
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