CIC protein instability contributes to tumorigenesis in glioblastoma

Capicua (CIC) is a transcriptional repressor that counteracts activation of genes downstream of receptor tyrosine kinase (RTK)/Ras/ERK signaling. It is well-established that tumorigenesis, especially in glioblastoma (GBM), is attributed to hyperactive RTK/Ras/ERK signaling. While CIC is mutated in o...

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Pubblicato in:Nat Commun
Autori principali: Bunda, Severa, Heir, Pardeep, Metcalf, Julie, Li, Annie Si Cong, Agnihotri, Sameer, Pusch, Stefan, Yasin, Mamatjan, Li, Mira, Burrell, Kelly, Mansouri, Sheila, Singh, Olivia, Wilson, Mark, Alamsahebpour, Amir, Nejad, Romina, Choi, Bethany, Kim, David, von Deimling, Andreas, Zadeh, Gelareh, Aldape, Kenneth
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368580/
https://ncbi.nlm.nih.gov/pubmed/30737375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08087-9
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