CIC protein instability contributes to tumorigenesis in glioblastoma

Capicua (CIC) is a transcriptional repressor that counteracts activation of genes downstream of receptor tyrosine kinase (RTK)/Ras/ERK signaling. It is well-established that tumorigenesis, especially in glioblastoma (GBM), is attributed to hyperactive RTK/Ras/ERK signaling. While CIC is mutated in o...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Bunda, Severa, Heir, Pardeep, Metcalf, Julie, Li, Annie Si Cong, Agnihotri, Sameer, Pusch, Stefan, Yasin, Mamatjan, Li, Mira, Burrell, Kelly, Mansouri, Sheila, Singh, Olivia, Wilson, Mark, Alamsahebpour, Amir, Nejad, Romina, Choi, Bethany, Kim, David, von Deimling, Andreas, Zadeh, Gelareh, Aldape, Kenneth
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368580/
https://ncbi.nlm.nih.gov/pubmed/30737375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08087-9
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