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CSIG-23. CIC PROTEIN INSTABILITY DRIVES CANCER PHENOTYPES IN GLIOBLASTOMA

The aggressive nature of glioblastoma (GBM) has been attributed to hyperactivation of receptor tyrosine kinases (RTK) and their downstream signaling pathways including Ras/ERK. Pharmacological agents directed against membrane bound RTKs and cytoplasmic kinases within the Ras/ERK signaling pathway ha...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Bunda, Severa, Heir, Pardeep, Metcalf, Julie, Pusch, Stefan, Zadeh, Gelareh, Aldape, Kenneth
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692980/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.217
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